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Related Experiment Videos

New features of the Blocks Database servers

J G Henikoff1, S Henikoff, S Pietrokovski

  • 1Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109-1024, USA.

Nucleic Acids Research
|December 10, 1998
PubMed
Summary
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The Blocks Database offers tools for protein family analysis and homology searching via web and email. New features enhance usability for unlisted families and gene isolation.

Area of Science:

  • Bioinformatics
  • Computational Biology
  • Genomics

Background:

  • The Blocks Database stores ungapped multiple sequence alignments of conserved protein regions from documented protein families.
  • Existing web and email servers facilitate homology searching and protein family relationship analysis.

Purpose of the Study:

  • To introduce new enhancements to the Blocks Database tools.
  • To extend the utility of the tools to imported multiple alignments of unlisted protein families.
  • To implement a novel strategy for gene isolation using a PCR primer designer.

Main Methods:

  • Utilizing web and email servers for homology searching and protein family analysis.
  • Implementing a multiple alignment processor for imported alignments.
  • Developing a PCR primer designer for gene isolation.

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Main Results:

  • Enhanced tools are now available for analyzing protein families not previously in the database.
  • A new strategy for gene isolation has been implemented.
  • Expanded capabilities for bioinformatics analysis and gene discovery.

Conclusions:

  • The Blocks Database enhancements improve accessibility and utility for a wider range of protein families.
  • The new PCR primer designer offers a novel approach to gene isolation.
  • These advancements facilitate deeper insights into protein family relationships and genetic research.