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ASDB: database of alternatively spliced genes

M S Gelfand1, I Dubchak, I Dralyuk

  • 1Institute of Protein Research, Russian Academy of Sciences, Pushchino 142292, Russia.

Nucleic Acids Research
|December 10, 1998
PubMed
Summary

A new database, the Alternatively Spliced Gene Database (ASDB), catalogs alternatively spliced genes and their protein products. This resource aids in understanding gene expression patterns across tissues and organisms.

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Area of Science:

  • Bioinformatics
  • Molecular Biology
  • Genomics

Background:

  • Alternative splicing is a key mechanism for increasing proteomic diversity.
  • Existing databases lack comprehensive information on alternatively spliced gene products and their expression.

Purpose of the Study:

  • To construct and present the Alternatively Spliced Gene Database (ASDB).
  • To provide a searchable resource for alternatively spliced gene products and expression patterns.

Main Methods:

  • Analysis of Swiss-Prot entries for alternatively spliced gene products.
  • Clustering of proteins potentially arising from the same alternatively spliced gene.
  • Database construction incorporating gene, product, and expression data.

Main Results:

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  • The ASDB contains approximately 1700 protein sequences.
  • The database facilitates searching for specific splicing variants within tissues, organisms, or transcripts.
  • ASDB provides a centralized resource for alternatively spliced gene information.

Conclusions:

  • The ASDB is a valuable tool for researchers studying alternative splicing.
  • This database enhances the understanding of gene product diversity and regulation.
  • ASDB is accessible online for broad scientific use.