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Related Experiment Videos

The Eukaryotic Promoter Database (EPD): recent developments

R C Périer1, T Junier, C Bonnard

  • 1Swiss Institute of Bioinformatics & Swiss Institute for Experimental Cancer Research, Ch. des Boveresses 155, 1066-Epalinges s/Lausanne, Switzerland.

Nucleic Acids Research
|December 10, 1998
PubMed
Summary
This summary is machine-generated.

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The Eukaryotic Promoter Database (EPD) provides curated eukaryotic RNA polymerase II promoter sequences with experimentally verified transcription start sites. It facilitates comparative analysis through structured data and improved web access.

Area of Science:

  • Genomics
  • Bioinformatics
  • Molecular Biology

Background:

  • Eukaryotic promoters are crucial regulatory DNA elements.
  • Accurate identification of transcription start sites (TSS) is essential for understanding gene regulation.
  • Existing databases may lack comprehensive, experimentally validated promoter data.

Purpose of the Study:

  • To present the Eukaryotic Promoter Database (EPD) as a comprehensive resource for eukaryotic RNA polymerase II promoters.
  • To provide experimentally verified transcription start site data.
  • To facilitate comparative sequence analysis of promoters.

Main Methods:

  • Compilation of eukaryotic POL II promoters with experimentally determined transcription start sites.
  • Annotation of promoter sequences including initiation site mapping data, cross-references, and bibliographic references.

Related Experiment Videos

  • Integration with nucleotide sequence databases (e.g., EMBL) and enhancement of web-based data retrieval.

    • Main Results:

    • EPD offers an annotated, non-redundant collection of eukaryotic POL II promoters.
    • Promoter sequences are accessible via pointers to nucleotide sequence entries.
    • The database structure supports dynamic extraction of promoter subsets for analysis.

    Conclusions:

    • EPD serves as a valuable, curated resource for researchers studying eukaryotic gene regulation.
    • Enhanced cross-referencing and user interfaces improve data accessibility and utility.
    • The database supports comparative genomics and functional studies of promoters.