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REBASE-restriction enzymes and methylases

R J Roberts¹, D Macelis

¹New England BioLabs, 32 Tozer Road, Beverly, MA 01915, USA. roberts@neb.com

Nucleic Acids Research

|December 10, 1998

Summary

REBASE is a comprehensive database for restriction enzymes and methylases, offering details on recognition sites, cleavage, and availability. It also lists homing endonucleases and provides access via web and FTP.

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Area of Science:

Molecular Biology
Bioinformatics

Background:

Restriction enzymes and methylases are crucial tools in molecular biology.
Databases are essential for organizing and accessing information on these enzymes.

Purpose of the Study:

To provide a comprehensive and accessible database of restriction enzymes, methylases, and homing endonucleases.
To facilitate the use of enzyme information in research and software applications.

Main Methods:

Data compilation from scientific literature and commercial sources.
Information dissemination through electronic mailings, anonymous FTP, and the World Wide Web.
Development of a dedicated website with enzyme-specific pages, search functionality, and downloadable files.

Main Results:

REBASE offers detailed information on recognition/cleavage sites and commercial availability for numerous enzymes.
The database includes a listing of homing endonucleases.
Specialized files compatible with various software packages are available.

Conclusions:

REBASE serves as a vital resource for researchers and bioinformaticians.
The database enhances accessibility and usability of enzyme data through multiple distribution channels and web-based tools.

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