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The Ribonuclease P Database

J W Brown1

  • 1Department of Microbiology, North Carolina State University, Raleigh, NC 27695, USA. jwbrown@mbio.ncsu.edu

Nucleic Acids Research
|December 10, 1998
PubMed
Summary

Ribonuclease P enzymes process tRNA precursors. In bacteria, the RNA component of Ribonuclease P acts as a ribozyme, catalyzing this essential reaction independently.

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Genetics

Background:

  • Ribonuclease P (RNase P) is a crucial enzyme complex.
  • It performs the 5' maturation of transfer RNA (tRNA) precursors.
  • RNase P is a ribonucleoprotein, comprising RNA and protein components.

Purpose of the Study:

  • To introduce the Ribonuclease P Database.
  • To provide a centralized resource for RNase P research.
  • To facilitate the study of tRNA precursor maturation.

Main Methods:

  • Compilation of known Ribonuclease P sequences.
  • Sequence alignment and analysis.
  • Development of secondary structure models.
  • Creation of three-dimensional models.
  • Data accessibility via the World Wide Web.

Main Results:

  • The Ribonuclease P Database is established and publicly accessible.
  • Contains diverse data including sequences, alignments, and structural models.
  • Highlights the catalytic role of RNA in bacterial RNase P (ribozyme activity).

Conclusions:

  • The Ribonuclease P Database serves as a valuable resource for researchers.
  • It supports the investigation of tRNA processing and ribozyme function.
  • Facilitates comparative genomics and structural biology of RNase P systems.

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