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Related Experiment Videos

Histone Sequence Database: sequences, structures, post-translational modifications and genetic loci

I Makalowska1, E S Ferlanti, A D Baxevanis

  • 1Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Building 49, Room 2C-76, Bethesda, MD 20892, USA.

Nucleic Acids Research
|December 10, 1998
PubMed
Summary
This summary is machine-generated.

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The Histone Sequence Database offers a comprehensive, searchable collection of histone sequences and structures. It resolves conflicting data and adds modifications and human genomic information for research.

Area of Science:

  • Biochemistry
  • Genomics
  • Bioinformatics

Background:

  • Histones are crucial proteins involved in DNA packaging and gene regulation.
  • Existing sequence databases may contain conflicting or incomplete information regarding histone data.
  • A centralized, annotated resource is needed for researchers studying histone biology.

Purpose of the Study:

  • To create and maintain a comprehensive, searchable database of histone and histone fold sequences and structures.
  • To identify and document conflicts between sequence entries from various source databases.
  • To integrate new data, including post-translational modifications and human genomic information.

Main Methods:

  • Compilation and annotation of publicly available histone and histone fold sequences.

Related Experiment Videos

  • Cross-referencing and conflict identification between multiple sequence databases.
  • Integration of post-translational modification data for core and linker histones.
  • Inclusion of human histone gene map loci and links to Online Mendelian Inheritance in Man (OMIM).

    • Main Results:

    • The Histone Sequence Database provides an annotated and searchable collection of histone data.
    • Conflicts in sequence entries from different sources are documented.
    • New data on histone post-translational modifications and human genomic loci are incorporated.
    • The database is freely accessible online.

    Conclusions:

    • The Histone Sequence Database serves as a valuable, centralized resource for histone research.
    • It enhances data accuracy by resolving sequence conflicts.
    • The integrated genomic and modification data facilitate further biological investigation.