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Related Experiment Videos

The Homeodomain Resource: sequences, structures and genomic information

S Banerjee-Basu1, E S Ferlanti, J F Ryan

  • 1Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health,Building 49, Room 2C-76, Bethesda, MD 20892-4431, USA.

Nucleic Acids Research
|December 10, 1998
PubMed
Summary

The Homeodomain Resource provides a unified database for homeodomain protein family information, including sequence, structure, and genomic data. This resource aids researchers studying these proteins and their roles in human genetic diseases.

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Area of Science:

  • Genomics
  • Molecular Biology
  • Bioinformatics

Background:

  • Homeodomain proteins are crucial transcription factors involved in development and disease.
  • Existing data on homeodomain proteins is fragmented across various databases.
  • A centralized resource is needed for comprehensive homeodomain research.

Purpose of the Study:

  • To create a comprehensive, integrated database for the homeodomain protein family.
  • To facilitate easy access to sequence, structure, and genomic information.
  • To link homeodomain proteins to human genetic diseases and mutations.

Main Methods:

  • Compilation of sequence data (full-length and domain-only).
  • Integration of structural data (X-ray and NMR) for proteins and complexes.

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  • Inclusion of genomic information (gene symbols, map locations, mutations).
  • Development of search engines for querying and data set assembly.

    • Main Results:

    • The Homeodomain Resource offers a unified platform for diverse homeodomain data.
    • Users can access sequence, structural, and genomic information.
    • The resource includes data on disease associations and mutations.
    • Integrated search tools enable efficient data retrieval and analysis.

    Conclusions:

    • The Homeodomain Resource serves as a valuable, centralized hub for homeodomain research.
    • It simplifies access to critical data for scientists.
    • The resource supports studies on homeodomain function, evolution, and disease relevance.