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Keio Mutation Database for eye disease genes (KMeyeDB)

S Minoshima1, S Mitsuyama, S Ohno

  • 1Department of Molecular Biology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.

Nucleic Acids Research
|December 10, 1998
PubMed
Summary

A new database, KMeyeDB, catalogs mutations in human eye disease genes. It offers graphical data presentation and analysis for 16 genes linked to 18 eye conditions.

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Area of Science:

  • Genetics
  • Ophthalmology
  • Bioinformatics

Background:

  • Genetic mutations are a significant cause of human eye diseases.
  • Comprehensive databases are crucial for understanding genotype-phenotype correlations in ophthalmology.
  • Existing resources may lack integrated graphical analysis tools for mutation data.

Purpose of the Study:

  • To construct and present KMeyeDB, a novel database for human eye disease gene mutations.
  • To provide a user-friendly interface with advanced graphical data presentation and analysis capabilities.
  • To consolidate mutation data for multiple genes and associated eye diseases.

Main Methods:

  • Development of a specialized database (KMeyeDB) using MutationView software.
  • Inclusion of mutation data for 16 distinct human genes implicated in eye diseases.

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  • Data compilation covering 18 different types of eye diseases.

    • Main Results:

    • KMeyeDB successfully integrates mutation data for 16 genes and 18 eye diseases.
    • The MutationView software enables a smooth user interface with graphical data presentation and analysis.
    • The database is publicly accessible via a web link for researchers.

    Conclusions:

    • KMeyeDB serves as a valuable, accessible resource for studying genetic mutations in eye diseases.
    • The integrated graphical analysis tools facilitate deeper insights into mutation data.
    • This database can aid in the diagnosis, research, and potential treatment of hereditary eye conditions.