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Related Experiment Videos

"Hidden" dUTPase sequence in human immunodeficiency virus type 1 gp120

C Abergel1, D L Robertson, J M Claverie

  • 1Laboratory of Structural and Genetic Information, CNRS EP-91, Marseille F-13402, France. chantal@igs.cnrs-mrs.fr

Journal of Virology
|December 16, 1998
PubMed
Summary

Human immunodeficiency virus type 1 (HIV-1) gp120 shares sequence similarity with human dUTPase. This suggests an ancestral dUTPase gene evolved into the primate lentivirus gp120 interaction region.

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Area of Science:

  • Virology
  • Molecular Biology
  • Enzymology

Background:

  • The essential eukaryotic enzyme dUTPase is found in various viral lineages.
  • Unlike nonprimate lentiviruses, dUTPase has not been identified in primate lentivirus genomes like HIV-1.
  • Previous studies noted fragmentary structural similarity between HIV-1 V3 loop and E. coli dUTPase.

Purpose of the Study:

  • To investigate potential sequence homology between HIV-1 gp120 and human dUTPase.
  • To determine if this homology extends to other primate lentivirus lineages.

Main Methods:

  • Utilized a novel approach to identify sequence similarities.
  • Comparative sequence analysis of viral and human dUTPase.

Main Results:

Related Experiment Videos

  • Identified a weak but significant sequence similarity between HIV-1 gp120 and human dUTPase.
  • Extended this finding to all primate lentivirus lineages.
  • Results support previous observations of structural similarity.

Conclusions:

  • An ancestral dUTPase gene likely evolved into the CD4 and cytokine receptor interacting region of primate lentivirus gp120.
  • This evolutionary link provides new insights into lentivirus adaptation and function.