Related Experiment Video
Updated: Oct 22, 2026

Investigating Mast Cell Secretory Granules; from Biosynthesis to Exocytosis
Published on: January 26, 2015
Molecular biology and role of histamine in physiological and pathological reactions. A review
1Department of Genetics, Cell- and Immunobiology, Semmelweis University of Medicine, Budapest.
Abstract:
Histamine is known to exhibit a wide variety of both physiological and pathologic functions in different tissues and cells, this amine is one of the most general mediators of the mammalian organism. Extracellular histamine action is believed to be mediated by binding to its specific cell-surface receptor(s) resulting in the converting the extracellular signal to intracellular events. Moreover, numerous studies suggest basic role for intracellular histamine as one of the intracellular messenger moieties. The functional consequences of the action of histamine involve many physiological and pathophysiological events, including allergy, neurotransmission and cell growth.
Related Concept Videos
Antibody Structure
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
Allergic Reactions
Allergic Drug Reactions
Asthma: Pathogenesis and Management
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Acid Suppressive Drugs for Peptic Ulcer Disease: Histamine H2-Receptor Antagonists
Allergic Reactions: Anaphylaxis

