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Prothrombin time in retinitis pigmentosa

M Dikshit1, M Vinchurkar, S M Sathye

  • 1Department of Chemistry, University of Pune, India.

Indian Journal of Ophthalmology
|December 16, 1998
PubMed
Summary

Patients with retinitis pigmentosa (RP) have elevated prothrombin times, regardless of disease onset or duration. This finding suggests prothrombin time may play a role in RP pathogenesis.

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Area of Science:

  • Ophthalmology
  • Hematology

Background:

  • Retinitis pigmentosa (RP) is a group of inherited retinal diseases.
  • The pathogenesis of RP is not fully understood.
  • Coagulation factors have been investigated in relation to various diseases.

Purpose of the Study:

  • To investigate prothrombin time in patients with primary retinitis pigmentosa.
  • To explore potential correlations between prothrombin time and clinical parameters of RP.

Main Methods:

  • Prothrombin time was measured in 87 patients with primary retinitis pigmentosa.
  • Patients were categorized into three clinical groups.
  • Data analysis included correlation with age of onset and disease duration.

Main Results:

  • All three clinical categories of RP patients exhibited higher than normal prothrombin times.
  • No significant correlation was found between prothrombin time and age of onset.
  • No significant correlation was found between prothrombin time and disease duration.

Conclusions:

  • Elevated prothrombin time is a characteristic finding in primary retinitis pigmentosa patients.
  • Further research into prothrombin time and related factors could elucidate RP pathogenesis.
  • Prothrombin time may represent a novel area for understanding and potentially managing RP.

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