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Exacerbation of the inflammatory response to Mycobacterium tuberculosis after antiretroviral therapy
1Department of Clinical Immunology, Royal Perth Hospital, WA. martfren@rph.health.wa.gov.au
The Medical Journal of Australia
|December 16, 1998
Abstract:
A patient with HIV infection was successfully treated for pulmonary tuberculosis, but pulmonary inflammation and lymphadenitis worsened dramatically after subsequent combination antiretroviral therapy. As this relapse coincided with development of a strong delayed-type hypersensitivity response to tuberculin and improved after treatment with the anti-inflammatory agent oxpentifylline, it was probably caused by restoration of pathogen-specific cellular immunity.