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Updated: Aug 11, 2026

Assessing Somatic Hypermutation in Ramos B Cells after Overexpression or Knockdown of Specific Genes
Published on: November 1, 2011
[DNA synthesis in lymphocytes of irradiated animals as affected by mitogens and Staphylococcal antigens]
L S Kholodna1, V K Pozur, T A Liubchenko
1T.Shevchenko University, Kyiv, Ukraine.
Abstract:
Proliferation activity of lymphocytes from rats was studied using micromethod of blast transformation reaction after exposure of X-ray irradiation (absorbed doses for animals are 0.5 and 1 Gr). The reducing of the functional activity of lymphocytes was found. There was difference in lymphocyte response induced by standard mitogens (PHA, ConA, LPS) and antigens of Staphylococcus protein A and peptidoglycan. The irradiation protective effects of Staphylococcus substances were found.
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