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[Biochemical mechanisms of the toxic effect of oxalates]
1Research Institute of Medico-ecological Problems, Ministry of Public Health of Ukraine, Chernovtsy.
Ukrainskii Biokhimicheskii Zhurnal (1978)
|December 16, 1998
Abstract:
The effect of oxalic acid and its salts on the biochemical systems of the homeostasis of white rats were investigated. It has been shown that oxalates inhibit enzymes of energy metabolism and cause the changes in parameters of nephrotoxicity, electrolyte balance of blood plasma and urine, lipid peroxidation, antiperoxidational defence system.
Insights
Oxalic acid and its salts disrupt white rat homeostasis by inhibiting energy metabolism enzymes. These compounds also negatively affect kidney function, electrolyte balance, and oxidative stress markers.
Area of Science:
- Biochemistry
- Toxicology
- Physiology
Context:
- Investigating the biochemical impact of oxalic acid and its salts.
- Focusing on the homeostatic systems of white rats.
- Examining effects on key metabolic and physiological parameters.
Purpose:
- To determine how oxalic acid and its salts affect biochemical systems.
- To elucidate the mechanisms of oxalate toxicity in mammals.
- To assess the impact on energy metabolism and oxidative stress.
Summary:
- Oxalates were found to inhibit enzymes crucial for energy metabolism.
- Significant alterations were observed in nephrotoxicity markers.
- Changes in blood plasma and urine electrolyte balance were documented.
- Lipid peroxidation levels increased, while the antiperoxidational defense system was affected.
Impact:
- Provides insights into the toxicological mechanisms of oxalates.
- Highlights the disruption of cellular energy production and homeostasis.
- Contributes to understanding oxalate-induced kidney damage and metabolic disturbances.