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Insulin-like growth factor-1 and insulin-like growth factor-binding protein-3 in women with premenstrual syndrome
A J Rapkin1, M Cedars, M Morgan
1University of California, Los Angeles Medical Center, Department of Obstetrics and Gynecology, 90095-1740, USA.
Objective:
To determine whether women with premenstrual syndrome (PMS) have aberrations of the GH axis as has been demonstrated in individuals with depression.
Design:
Prospective trial.
Setting:
Department of Obstetrics and Gynecology, University of California, Los Angeles.
Patient(S):
After prospective screening, 32 healthy women with PMS and 32 asymptomatic controls completed the study.
Intervention(S):
Subjects completed a daily PMS symptom diary and a Beck Depression Inventory. They underwent phlebotomy 5 days and 12 days after the LH midcycle surge, which was identified with the use of a urinary LH detection kit.
Main Outcome Measure(S):
Serum levels of insulin-like growth factor-1 (IGF-1), insulin-like growth factor-binding protein-3 (IGFBP-3), E2, and progesterone.
Result(S):
Levels of IGF-1, IGFBP-3, E2, and progesterone did not differ between women with prospectively documented PMS and control subjects.
Conclusion(S):
Premenstrual syndrome and affective disorder share common symptoms and possibly a common cause. Biochemical markers such as alterations in the somatotropic system often are associated with major depression. Levels of IGF-1 and IGFBP-3 did not differ between women with PMS and control subjects, supporting the concept that PMS and endogenous depression are biologically distinct entities.
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