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Related Concept Videos

Phagocytosis00:41

Phagocytosis

Cells pull particles inward and engulf them in spherical vesicles in an energy-requiring process called endocytosis. Phagocytosis (“cellular eating”) is one of three major types of endocytosis. Cells use phagocytosis to take in large objects—such as other cells (or their debris), bacteria, and even viruses.The objective of phagocytosis is often destruction. Cells use phagocytosis to eliminate unwelcome visitors, like pathogens (e.g., viruses and bacteria). It is perhaps unsurprising, that many...
Phagocytosis00:41

Phagocytosis

Cells pull particles inward and engulf them in spherical vesicles in an energy-requiring process called endocytosis. Phagocytosis ("cellular eating") is one of three major types of endocytosis. Cells use phagocytosis to take in large objects, such as other cells (or their debris), bacteria, and even viruses.
The objective of phagocytosis is often destruction. Cells use phagocytosis to eliminate unwelcome visitors, like pathogens (e.g., viruses and bacteria). Many immune system cells, including...
Phagocytosis of Apoptotic Cells01:17

Phagocytosis of Apoptotic Cells

Cells undergoing apoptosis form apoptotic bodies that must be removed immediately to prevent inflammation, autoimmune diseases, and necrosis. Phagocytosis is carried out by professional phagocytes such as macrophages or  immature dendritic cells. Non-professional phagocytes such as  epithelial cells and fibroblasts also take part in this process; however, they are not as effective as professional phagocytes. 
Normal cells contain receptors that prevent them from being recognized by phagocytes.
Disorders of Leukocytes01:27

Disorders of Leukocytes

Leukocyte disorders can lead to either leukopenia, characterized by an abnormally low leukocyte count, or leukocytosis, marked by a very high leukocyte number.
Leukopenia may result from bone marrow disorders, autoimmune diseases, and infectious diseases. For example, conditions such as multiple myeloma and aplastic anemia can impair the bone marrow's ability to produce adequate leukocytes. Similarly, autoimmune diseases like lupus and viral infections such as HIV can prompt the immune system...
Immune Surveillance by NK Cells and Phagocytes01:25

Immune Surveillance by NK Cells and Phagocytes

Immune surveillance is an integral part of the innate immune system, involving the continuous monitoring of peripheral tissues to detect and respond to pathogens, infected cells, or cancerous cells. This surveillance is conducted primarily by natural killer (NK) cells and phagocytes, which employ distinct but complementary mechanisms to identify and eliminate threats.
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
Immunodeficiency Diseases01:25

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency disorders...

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Related Experiment Video

Updated: Jun 18, 2026

High Throughput Fluorometric Technique for Assessment of Macrophage Phagocytosis and Actin Polymerization
09:22

High Throughput Fluorometric Technique for Assessment of Macrophage Phagocytosis and Actin Polymerization

Published on: November 27, 2014

Disorders of phagocyte function

W L Weston

    Archives of Dermatology
    |November 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Phagocytic defects causing skin issues are increasingly recognized. New assays help identify these defects, clarifying the role of phagocytic leukocytes in skin immunity.

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    Last Updated: Jun 18, 2026

    High Throughput Fluorometric Technique for Assessment of Macrophage Phagocytosis and Actin Polymerization
    09:22

    High Throughput Fluorometric Technique for Assessment of Macrophage Phagocytosis and Actin Polymerization

    Published on: November 27, 2014

    "Phagosome Closure Assay" to Visualize Phagosome Formation in Three Dimensions Using Total Internal Reflection Fluorescent Microscopy (TIRFM)
    10:07

    "Phagosome Closure Assay" to Visualize Phagosome Formation in Three Dimensions Using Total Internal Reflection Fluorescent Microscopy (TIRFM)

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    Use of a Monocyte Monolayer Assay to Evaluate Fcγ Receptor-mediated Phagocytosis
    06:27

    Use of a Monocyte Monolayer Assay to Evaluate Fcγ Receptor-mediated Phagocytosis

    Published on: January 2, 2017

    Area of Science:

    • Immunology
    • Dermatology
    • Cell Biology

    Background:

    • Phagocytic defects are increasingly linked to skin manifestations.
    • Understanding these defects is crucial for host defense mechanisms.

    Purpose of the Study:

    • To highlight the growing reports of phagocytic defects with cutaneous signs.
    • To emphasize the importance of phagocyte assays in diagnosing these conditions.
    • To elucidate the role of phagocytic leukocytes in skin immunity.

    Main Methods:

    • Review of reported cases of phagocytic defects with skin symptoms.
    • Discussion on the utility and increasing availability of phagocyte function assays.

    Main Results:

    • An increasing number of phagocytic defects presenting with skin manifestations are being identified.
    • Phagocyte assays are becoming more accessible for diagnostic purposes.

    Conclusions:

    • Detection of phagocyte defects through assays is vital.
    • This detection aids in understanding the specific cellular events involved.
    • It clarifies the critical role of phagocytic leukocytes in maintaining skin's immune defenses.