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A Mouse Model of in Utero Transplantation
Published on: January 27, 2011
Experience with intrauterine transfusions for severe Rh alloimmunization in a developing country
S C Gupte1, C P Lulla, S S Kulkarni
1Institute of Immunohaematology, Indian Council of Medical Research, Parel, Mumbai. dir@icmriih.ren.nic.in
The Journal of Maternal-Fetal Medicine
|December 16, 1998
Summary
Intrauterine transfusions (IUTs) for severe Rh alloimmunization in developing countries showed a 55.6% survival rate. Strategies are needed to improve outcomes, addressing late referrals and blood availability for Rh-negative pregnancies.
Area of Science:
- Maternal-Fetal Medicine
- Hematology
Background:
- Severe Rh alloimmunization poses significant risks to fetuses.
- Intrauterine transfusions (IUTs) are a critical intervention for affected pregnancies.
- Developing countries face unique challenges in managing Rh alloimmunization.
Purpose of the Study:
- To report experience with intrauterine transfusions (IUTs) for severe Rh alloimmunization.
- To identify factors influencing outcomes in a developing country context.
- To discuss strategies for improving IUT efficacy and survival rates.
Main Methods:
- Retrospective analysis of 67 IUTs in 27 cases of severe Rh alloimmunization.
- Utilized ultrasonography (USG) and amniotic fluid analysis for assessment.
- Monitored fetal hematocrit (HCT) and donor red cell percentage post-transfusion.
Main Results:
- Overall survival rate was 55.6%.
- Factors like late referral, severe anemia, and delayed transfusion impacted outcomes.
- Ascites and fetal anemia severity correlated with stillbirths.
Conclusions:
- IUT is a viable but challenging procedure in resource-limited settings.
- Improving referral timing and blood availability are crucial for better outcomes.
- Further strategies are needed to enhance fetal survival in Rh alloimmunization.
