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In vivo correlation between blood T2* and oxygen saturation
D Li1, D J Waight, Y Wang
1Department of Radiology, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA. debiao@mirlink.wustl.edu
Journal of Magnetic Resonance Imaging : JMRI
|December 16, 1998
Summary
This study shows that blood T2* measurements using MRI reliably reflect blood oxygen saturation levels in pigs. The relationship is linear, offering a new way to assess oxygenation non-invasively.
Area of Science:
- Biomedical Engineering
- Medical Imaging
- Physiology
Background:
- Assessing blood oxygen saturation non-invasively is crucial for clinical monitoring.
- Magnetic Resonance (MR) techniques offer potential for quantitative physiological measurements.
- Previous MR methods for blood T2* assessment require further in vivo validation.
Purpose of the Study:
- To investigate the in vivo relationship between blood T2* and blood oxygen saturation.
- To validate a previously proposed MR technique for reliable in vivo blood T2* measurement.
- To establish a quantitative correlation between blood T2* and oxygen saturation.
Main Methods:
- Inducing a wide range of blood oxygen saturation levels in pigs by adjusting ventilation.
- Measuring blood T2* in vivo within the abdominal aorta and inferior vena cava.
- Utilizing a previously established MR technique for T2* quantification.
Main Results:
- The proposed MR technique reliably measured blood T2* in vivo across varied oxygen saturation levels.
- A strong correlation was observed between blood T2* values and blood oxygen saturation.
- The relationship between in vivo blood T2* and oxygen saturation was approximated by a linear function.
Conclusions:
- In vivo blood T2* measurement using the proposed MR technique is feasible and reliable.
- Blood T2* serves as a sensitive indicator of blood oxygen saturation over a broad range.
- The linear relationship facilitates quantitative assessment of blood oxygenation using MR.