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HLA frequencies in less common arthropathies
Annals of the Rheumatic Diseases
|June 1, 1976
Summary
The human leukocyte antigen B27 (HLA-B27) allele was not more common in patients with rubella-induced joint pain. This finding contrasts with other arthritis types where HLA-B27 is prevalent.
Area of Science:
- Immunogenetics
- Rheumatology
- Viral Arthropathies
Background:
- The human leukocyte antigen B27 (HLA-B27) is strongly associated with certain inflammatory arthropathies.
- Rubella virus infection can cause transient arthropathy, but its association with HLA-B27 is not well-established.
Purpose of the Study:
- To investigate the incidence of HLA-B27 in patients experiencing rubella-associated arthropathy.
- To compare HLA-B27 frequencies in rubella arthropathy patients with control groups.
Main Methods:
- Case-control study comparing HLA-B27 allele frequency.
- Inclusion of patients with rubella arthropathy, Westminster controls, and patients with post-dysenteric arthritis.
Main Results:
- No statistically significant increase in HLA-B27 incidence was observed in patients with rubella arthropathy compared to Westminster controls.
- Patients with arthritis secondary to dysentery exhibited a high prevalence of the HLA-B27 allele, serving as a positive control group.
Conclusions:
- The HLA-B27 allele does not appear to be a significant risk factor for developing arthropathy following rubella infection.
- The immunogenetic basis of rubella arthropathy likely differs from that of other HLA-B27-associated spondyloarthropathies.