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Related Experiment Videos

CD100 is a leukocyte semaphorin

S Delaire1, A Elhabazi, A Bensussan

  • 1Unité INSERM U448, Faculté de médecine, Creteil, France. delair@im3.inserm.fr

Cellular and Molecular Life Sciences : CMLS
|December 16, 1998
PubMed
Summary

CD100, a T lymphocyte activation molecule, associates with CD45 and a Ser/Thr kinase. As a semaphorin family member, CD100 suggests semaphorins may function beyond the nervous system in immunity.

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Area of Science:

  • Immunology
  • Cell Biology
  • Neuroscience

Background:

  • CD100 is an activation molecule on human T lymphocytes.
  • Its triggering induces costimulatory signals via distinct epitopes.
  • CD100 associates with intracellular molecules in T cells.

Purpose of the Study:

  • To detail the molecular interactions of CD100 in T cells.
  • To explore the implications of CD100's classification within the semaphorin family.
  • To investigate potential roles of semaphorins in non-nervous system physiology.

Main Methods:

  • Analysis of CD100 association with CD45.
  • Investigation of CD100 interaction with a Ser/Thr kinase.
  • Review of CD100's classification within the semaphorin gene family.

Main Results:

  • CD100 physically associates with CD45, impacting both molecules.
  • CD100's cytoplasmic domain interacts with a Ser/Thr kinase.
  • CD100 is identified as a member of the semaphorin gene family.

Conclusions:

  • CD100 exhibits complex molecular associations within T cells.
  • CD100's semaphorin identity suggests broader physiological roles for this protein family.
  • Semaphorins may be involved in immune system regulation beyond their known neural functions.

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