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Related Experiment Videos

Betadrenoceptors in urinary bladder

D K Ganguly, J R Vedasiromoni

    Archives Internationales De Pharmacodynamie Et De Therapie
    |August 1, 1976
    PubMed
    Summary

    This study found that beta-adrenoceptors in rat and guinea-pig bladders can be inhibited. Propranolol reversed these inhibitory effects, confirming the presence of these receptors.

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    Area of Science:

    • Pharmacology
    • Urology
    • Adrenergic receptor research

    Background:

    • The urinary bladder's function is regulated by the autonomic nervous system.
    • Adrenergic receptors play a role in smooth muscle contraction and relaxation.
    • Previous research has not fully elucidated the role of beta-adrenoceptors in the urinary bladder.

    Purpose of the Study:

    • To investigate the presence and function of inhibitory beta-adrenoceptors in the urinary bladder of rats and guinea-pigs.
    • To determine the effect of specific adrenergic drugs on bladder responses.
    • To characterize the role of beta-adrenoceptors in modulating bladder activity.

    Main Methods:

    • Experiments were conducted on isolated rat and guinea-pig urinary bladders.
    • Responses to hypogastric nerve stimulation and exogenous acetylcholine were measured.
    • The effects of dibenzyline, isoproterenol, adrenaline, and propranolol were assessed.

    Main Results:

    • Isoproterenol and adrenaline impaired bladder responses to hypogastric nerve stimulation and acetylcholine.
    • These inhibitory effects were dose-dependent and ranged from 60-80% maximal inhibition.
    • The inhibitory effects were reversed by propranolol, a beta-adrenergic antagonist.

    Conclusions:

    • The study provides strong evidence for the presence of inhibitory beta-adrenoceptors in the urinary bladder of rats and guinea-pigs.
    • These receptors play a significant role in modulating bladder function.
    • The findings contribute to understanding the neuropharmacology of the lower urinary tract.

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