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Updated: Oct 26, 2026

Multi-scale Analysis of Bacterial Growth Under Stress Treatments
Published on: November 28, 2019
Application of artificial neural networks as a non-linear modular modeling technique to describe bacterial growth in
A H Geeraerd1, C H Herremans, C Cenens
1BioTeC-Bioprocess Technology and Control, Department of Food and Microbial Technology, Katholieke Universiteit Leuven, Heverlee, Belgium.
Abstract:
In many chilled, prepared food products, the effects of temperature, pH and %NaCl on microbial activity interact and this should be taken into account. A grey box model for prediction of microbial growth is developed. The time dependence is modeled by a Gompertz model-based, non-linear differential equation. The influence of temperature, pH and %NaCl reflected in the model parameters is described by using low-complexity, black box artificial neural networks (ANN's). The use of this non-linear modeling technique makes it possible to describe more accurately interacting effects of environmental factors when compared with classical predictive microbiology models. When experimental results on the influence of other environmental factors become available, the ANN models can be extended simply by adding more neurons and/or layers.
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