[Late lesions in cerebrocortical necrosis (CCN) of cattle]

The brains of three young fattening bulls in which cerebrocortical necrosis had been cured by intensive vitamin-B1 treatment were histologically examined six, eight, and ten months after the clinical outbreak of the disease. Shrinkage foci were detected in the cerebral cortex, their localisation and extension depending on the course of the past disease. Part of the cerebrocortical centre was void, with differentiated amounts of fatty granular cells being scattered in regions of it. The findings were taken to indicate almost complete decomposition and resorption of the liquefied necrotic tissue. Glios cicatrisation occurred in places. A vacumn that had resulted from depression of the brain surface was filled up by proliferating loose connective tissue and vessels in the leptomeningeal region. The weight increase of fattening bulls with a case history of cerebrocortical nectosis was found to be much worse than that recordable from animals with no pathological record. Continued keeping of such cured animals, therefore, seems to be of poor economy.