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"Rhabdoid" meningioma: an aggressive variant
A Perry1, B W Scheithauer, S L Stafford
1Department of Laboratory Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA. aperry@pathology.wustl.edu
The American Journal of Surgical Pathology
|December 16, 1998
Summary
Rhabdoid meningiomas, characterized by specific cell morphology, are aggressive tumors. This rhabdoid phenotype indicates malignant transformation and is associated with a poor prognosis and high recurrence rates.
Area of Science:
- Neuropathology
- Oncology
- Surgical Pathology
Background:
- Rhabdoid morphology in tumors is often linked to poor prognosis.
- Meningiomas are tumors arising from the meninges.
Purpose of the Study:
- To investigate the clinical and histological features of meningiomas with rhabdoid morphology.
- To determine the prognostic significance of rhabdoid features in meningiomas.
Main Methods:
- Histological analysis of 15 meningiomas with rhabdoid features.
- Immunohistochemical and ultrastructural examination.
- Clinical follow-up of patients.
Main Results:
- Rhabdoid morphology was defined by specific cellular and inclusion characteristics.
- Nine of 15 cases showed histological malignancy (brain invasion or anaplasia).
- 13 patients (87%) experienced recurrence, and 8 (53%) died of disease.
Conclusions:
- Rhabdoid meningiomas are highly aggressive tumors.
- The rhabdoid phenotype serves as a marker for malignant transformation in meningiomas.
- These tumors are associated with a poor prognosis and high recurrence rates.