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Published on: May 18, 2016
Serological similarities between hyperreactive malarial splenomegaly and splenic lymphoma in west Africa
S Wallace1, G Bedu-Addo, T R Rutherford
1Division of Haematology, St George's Hospital Medical School, London, UK.
Abstract:
In West Africa hyperreactive malarial splenomegaly (HMS) and splenic lymphoma with villous lymphocytes (SLVL) are demographically and clinically indistinguishable. Determination of lymphocyte clonality is needed to differentiate clearly between these 2 disorders. To obtain evidence to support our hypothesis that HMS and SLVL are aetiologically related we studied the serological profile of malaria-related antibodies in HMS and SLVL in West Africa. We found that in SLVL total immunoglobulin M and antimalarial antibody levels were markedly raised, a combination which is characteristic of HMS. These findings strongly support a developmental relationship between HMS and SLVL in tropical Africa and implicate malaria in this process.
