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Synthesis of hydantoins via N,N'-ureas derived from polymer-bound amino acids
M Bauser1, M Winter, C A Valenti
1University of Tübingen, Institute of Organic Chemistry, Germany.
Molecular Diversity
|January 1, 1997
Abstract:
Starting from carboxy-linked amino acids on trityl functionalized polystyrene resin a highly efficient solid-phase synthesis of hydantoins via N,N'-ureas was elaborated. The polymer-bound hydantoins can be used as a scaffolds for further combinatorial transformations, such as alkylation. Cleavage from the resins yielded the corresponding hydantoins in good yields and purities as shown by ESI-MS and HPLC.