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Related Experiment Videos

Prolonged pulseless perfusion in unanesthetized calves

G G Johnston, F Hammill, U Marzec

    Archives of Surgery (Chicago, Ill. : 1960)
    |November 1, 1976
    PubMed
    Summary

    Prolonged nonpulsatile left ventricular (LV) bypass using a centrifugal pump showed no adverse effects in calves. This study supports the safety of pulseless perfusion for extended durations.

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    Area of Science:

    • Cardiovascular Surgery
    • Biomedical Engineering
    • Physiology

    Background:

    • Left ventricular (LV) assist devices are crucial for cardiac support.
    • Understanding the physiological impact of nonpulsatile versus pulsatile blood flow is essential for device development.

    Purpose of the Study:

    • To evaluate the physiological effects of prolonged nonpulsatile left ventricular bypass in an animal model.
    • To compare outcomes between nonpulsatile and pulsatile cardiopulmonary bypass.

    Main Methods:

    • Nine calves underwent prolonged nonpulsatile LV bypass using a centrifugal blood pump for up to two weeks.
    • Data were compared to prebypass controls and seven calves receiving pulsatile bypass for up to 35 days.
    • Physiological parameters including heart rate, aortic pressure, cardiac output, systemic vascular resistance, and serum markers were monitored.

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    Main Results:

    • Nonpulsatile bypass led to a 20% increase in heart rate and a 10% increase in aortic pressure.
    • Cardiac output and systemic vascular resistance showed similar trends in both groups initially, with resistance decreasing and cardiac output increasing over time in the nonpulsatile group.
    • Serum renin, lactate, pyruvate, and creatinine clearances remained within normal limits, with no significant body weight changes.

    Conclusions:

    • Prolonged pulseless perfusion via nonpulsatile LV bypass did not result in significant adverse physiological effects in the studied calves.
    • These findings suggest that nonpulsatile blood flow may be a viable option for extended cardiac support.