Therapeutic strategies based on immunological hypotheses of Alzheimer's disease

There are several findings demonstrating the importance of inflammatory or immunological processes in the etiopathogenesis of Alzheimer's disease (AD). Several studies on nonsteroidal anti-inflammatory drugs (NSAID) give evidence for a therapeutic effect of these drugs in AD, among other the prospective double-blind placebo-controlled study on indomethacin, strongly support the therapeutic effect of these agents. Possibly also the therapeutic effects of propentofylline might be interpreted in the light of this theory.