Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Decrease in plasma levels of vasoactive intestinal polypeptide in short bowel syndrome: experimental study

J C Martin Del Olmo1, M A Carbajo Caballero, J I Blanco Alvarez

  • 1Department of General Surgery, Hospital de Medina del Campo, Valladolid, Spain.

International Surgery
|December 16, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Carotid glomus in childhood: presentation of a clinical case.

Cirugia pediatrica : organo oficial de la Sociedad Espanola de Cirugia Pediatrica·2021
Same author

[Informed consents readability in vascular surgery and its progress over time].

Journal of healthcare quality research·2020
Same author

Outcomes of laparoscopic management of multicompartmental pelvic organ prolapse.

Surgical endoscopy·2018
Same author

Design of a New Risk Score in Critical Limb Ischaemia: The ERICVA Model.

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery·2015
Same author

Reflux patterns and risk factors of primary varicose veins’ clinical severity.

Phlebology·2012
Same author

Gastric pouch carcinoma after gastric bypass for morbid obesity.

Obesity surgery·2005

Massive intestinal resection (MIR) in pigs led to a significant decrease in vasoactive intestinal polypeptide (VIP) levels. This finding suggests VIP may indicate intestinal adaptation after short bowel syndrome.

Area of Science:

  • Gastroenterology
  • Endocrinology
  • Surgical Research

Background:

  • Short bowel syndrome (SBS) is a malabsorptive condition often resulting from massive intestinal resection (MIR).
  • Vasoactive intestinal polypeptide (VIP) plays a crucial role in intestinal function and adaptation.

Purpose of the Study:

  • To investigate the changes in plasma vasoactive intestinal polypeptide (VIP) levels in an experimental model of massive intestinal resection (MIR).
  • To assess the correlation between VIP levels, steatorrhea, and intestinal adaptation following MIR.

Main Methods:

  • A minipig model of MIR was established with 20 animals divided into control and MIR groups.
  • Plasma VIP levels and steatorrhea were measured at four time points: basal, 1 week, 2 weeks, and 24 weeks post-surgery.

Related Experiment Videos

Main Results:

  • Massive intestinal resection (MIR) resulted in a progressive and statistically significant decrease in mean plasma VIP levels at 2 and 24 weeks post-surgery.
  • Increased steatorrhea was observed in the MIR group, consistent with malabsorption.

Conclusions:

  • Plasma VIP levels significantly decrease after massive intestinal resection (MIR), likely due to the loss of intestinal tissue.
  • VIP may serve as a potential biomarker for monitoring the progression of intestinal adaptation in short bowel syndrome (SBS).