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Relation among left ventricular mass, insulin resistance, and blood pressure in nonobese subjects

R A Phillips1, L R Krakoff, A Dunaif

  • 1Mount Sinai Medical Center, New York, New York 10029, USA. robert_phillips@smtplink.mssm.edu

The Journal of Clinical Endocrinology and Metabolism
|December 16, 1998
PubMed

Insights

Insulin resistance, not just blood pressure, contributes to increased left ventricular mass in hypertensive individuals. Improving insulin sensitivity may help prevent cardiac issues in those with high-normal blood pressure.

Area of Science:

  • Cardiology
  • Metabolic Health
  • Hypertension Research

Background:

  • Left ventricular mass (LVM) predicts cardiovascular events.
  • Identifying factors influencing LVM is crucial for prevention.
  • Hypertension is a known risk factor for cardiac remodeling.

Purpose of the Study:

  • To investigate the independent contributions of arterial blood pressure (BP) and insulin resistance to LVM.
  • To explore these relationships in nonobese, non-diabetic individuals with borderline or mild hypertension.

Main Methods:

  • Quantitative assessment of insulin sensitivity index (SI) using iv glucose tolerance test.
  • 24-hour ambulatory BP monitoring for BP characterization.
  • Two-dimensional echocardiography for LVM index (LVMI) determination.

Main Results:

  • LVMI directly correlated with 24-hour mean BP (r=0.47; P=0.01).
  • LVMI significantly related to SI (r=-0.43; P=0.02).
  • The association between LVMI and SI remained significant after adjusting for BP (P < 0.05).

Conclusions:

  • Insulin sensitivity is an independent predictor of LVM in nonobese individuals with high-normal BP.
  • Insulin sensitivity may modulate left ventricular growth.
  • Improving insulin sensitivity, alongside BP reduction, is important for preventing left ventricular hypertrophy in hypertensives.

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