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The function of the p190 Rho GTPase-activating protein is controlled by its N-terminal GTP binding domain

N Tatsis1, D A Lannigan, I G Macara

  • 1Center for Cell Signaling, University of Virginia, Charlottesville, Virginia 22908, USA.

The Journal of Biological Chemistry
|December 16, 1998
PubMed
Summary

The N-terminal GTP binding domain of p190 regulates its Rho/Rac GTPase-activating protein (GAP) activity within cells. This regulation is crucial for cell morphology and Jun kinase (JNK) activation.

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