Platelets stored in a new-generation container differences between plasma and platelet additive solution II

Area of Science:

• Transfusion Medicine
• Biomaterials Science
• Hematology

Background:

• A novel 1.3-liter polyolefin platelet storage container (PL 2410) was developed to improve platelet concentrate (PC) preservation.
• This container features increased gas permeability and a larger surface area for enhanced storage capacity.

Purpose of the Study:

• To evaluate the storage capacity of the new platelet container for PCs suspended in plasma and platelet additive solution (PAS II).
• To assess the impact of platelet yield on pH maintenance over a 7-day storage period.

Main Methods:

• Platelet concentrates (PCs) were prepared using either plasma (PCs-PL) or PAS II (PCs-PAS) with varying platelet yields.
• PCs were stored on a flatbed shaker at 22°C ± 2°C for 7 days.
• Evaluations included platelet counts, pH, pO2, pCO2, and swirling score.

Main Results:

• Platelet yields ranged from 1.5 to 5.5 x 10(11) platelets/unit.
• On day 7, PCs-PL with yields >4.5 x 10(11)/unit showed pH <6.8 (5.91-6.79).
• On day 7, 7/8 PCs-PAS units with yields >4.0 x 10(11)/unit showed pH <6.8 (6.31-6.70).

Conclusions:

• The new container maintained pH >6.8 for 7 days in PCs-PL with yields up to 4.5 x 10(11)/unit.
• For PCs-PAS, the maximum yield for comparable pH maintenance was 4.0 x 10(11)/unit.
• This indicates the container's efficacy in preserving platelet quality within specific yield ranges.