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Related Experiment Videos

Platelets stored in a new-generation container differences between plasma and platelet additive solution II

J de Wildt-Eggen1, J G Schrijver, W M Smid

  • 1Red Cross Bloodbank IJssellanden, Zwolle, The Netherlands.

Vox Sanguinis
|December 16, 1998
PubMed
Summary

New platelet storage containers maintain pH above 6.8 for 7 days. Platelet concentrates in plasma are stable up to 4.5 x 10(11) units, while those in PAS II solution are stable up to 4.0 x 10(11) units.

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Area of Science:

  • Transfusion Medicine
  • Biomaterials Science
  • Hematology

Background:

  • A novel 1.3-liter polyolefin platelet storage container (PL 2410) was developed to improve platelet concentrate (PC) preservation.
  • This container features increased gas permeability and a larger surface area for enhanced storage capacity.

Purpose of the Study:

  • To evaluate the storage capacity of the new platelet container for PCs suspended in plasma and platelet additive solution (PAS II).
  • To assess the impact of platelet yield on pH maintenance over a 7-day storage period.

Main Methods:

  • Platelet concentrates (PCs) were prepared using either plasma (PCs-PL) or PAS II (PCs-PAS) with varying platelet yields.
  • PCs were stored on a flatbed shaker at 22°C ± 2°C for 7 days.
  • Evaluations included platelet counts, pH, pO2, pCO2, and swirling score.

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Main Results:

  • Platelet yields ranged from 1.5 to 5.5 x 10(11) platelets/unit.
  • On day 7, PCs-PL with yields >4.5 x 10(11)/unit showed pH <6.8 (5.91-6.79).
  • On day 7, 7/8 PCs-PAS units with yields >4.0 x 10(11)/unit showed pH <6.8 (6.31-6.70).

Conclusions:

  • The new container maintained pH >6.8 for 7 days in PCs-PL with yields up to 4.5 x 10(11)/unit.
  • For PCs-PAS, the maximum yield for comparable pH maintenance was 4.0 x 10(11)/unit.
  • This indicates the container's efficacy in preserving platelet quality within specific yield ranges.