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[Alpha-fetoprotein: normal values in amniotic fluid between 14 and 21 weeks]

D Maestri1, M T Sanseverino, N Cheinquer

  • 1Unidade de Genética Médica, Imunologia, Ginecologia e Obstetrícia, Hospital de Clínicas de Porto Alegre, RS.

Revista Da Associacao Medica Brasileira (1992)
|December 16, 1998
PubMed
Summary

This study establishes normal amniotic fluid alphafetoprotein levels for pregnancies between 14 and 21 weeks. These reference values aid in detecting neural tube defects and other fetal malformations.

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Area of Science:

  • Prenatal diagnostics
  • Biochemistry
  • Maternal-fetal medicine

Context:

  • Amniotic fluid alphafetoprotein (AFP) is a key biomarker in prenatal screening.
  • Establishing normative data is crucial for accurate interpretation of AFP levels.
  • Previous studies may lack specific reference ranges for certain gestational ages or populations.

Purpose:

  • To define normal ranges for amniotic fluid AFP in pregnancies from 14 to 21 weeks.
  • To provide a local reference standard for the Hospital de Clínicas de Porto Alegre.
  • To facilitate the early detection of fetal abnormalities.

Summary:

  • AFP levels were measured in 109 normal pregnancies using enzyme immunoassay.
  • Median AFP values were calculated for each gestational week from 14 to 21 weeks.

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  • Normal median AFP values ranged from 16.32 KUI/ml at 14 weeks to 4.47 KUI/ml at 21 weeks.

    • Impact:

    • Enables risk assessment for neural tube defects.
    • Supports the identification of fetuses requiring further sonographic evaluation for malformations.
    • Enhances the utility of amniotic fluid samples for broader diagnostic purposes.