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Related Experiment Videos

Increased 2,3-diphosphoglycerate during normocapnic hypobaric hypoxia

A Cymerman, J T Maher, J C Cruz

    Aviation, Space, and Environmental Medicine
    |October 1, 1976
    PubMed
    Summary

    Hypobaric hypoxia exposure increases 2,3-diphosphoglycerate (2,3-DPG) levels, enhancing oxygen transport. This altitude adaptation occurs even without respiratory alkalosis, challenging previous assumptions.

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    Area of Science:

    • Physiology
    • Altitude Medicine
    • Respiratory Physiology

    Background:

    • Altitude exposure induces physiological adaptations to improve oxygen delivery.
    • The role of respiratory alkalosis in altitude-induced 2,3-diphosphoglycerate (2,3-DPG) increases is debated.
    • Understanding these adaptations is crucial for managing high-altitude environments.

    Purpose of the Study:

    • To investigate the effect of hypobaric hypoxia with and without carbon dioxide (CO2) supplementation on 2,3-DPG levels.
    • To determine if elevated 2,3-DPG can occur without respiratory alkalosis.
    • To examine concurrent changes in P50 and mean corpuscular hemoglobin concentration.

    Main Methods:

    • Two groups of subjects were exposed to hypobaric hypoxia for 96 hours.

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  • One group received 3.8% CO2 supplementation, while the other did not.
  • Measurements included barometric pressure, end-tidal PO2, 2,3-DPG, P50, and mean corpuscular hemoglobin concentration.

    • Main Results:

    • 2,3-DPG levels significantly increased in both groups after 24 hours and remained elevated.
    • The CO2-supplemented group showed higher 2,3-DPG levels at 48 and 72 hours.
    • P50 showed similar changes, while mean corpuscular hemoglobin concentration decreased after 48 hours, more so in the CO2 group.

    Conclusions:

    • Hypobaric hypoxia can increase 2,3-DPG levels independently of respiratory alkalosis.
    • CO2 supplementation may influence the magnitude of 2,3-DPG elevation.
    • These findings suggest a more complex mechanism for altitude adaptation than previously understood.