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Cardiac remodeling as a consequence and cause of progressive heart failure

K Kurrelmeyer1, D Kalra, B Bozkurt

  • 1Winters Center for Heart Failure Research, Houston, Texas, USA.

Clinical Cardiology
|December 16, 1998
PubMed

Insights

Cardiac remodeling, including increased left ventricular (LV) volume and mass, worsens heart failure outcomes. This review explores the cellular and chamber-level mechanisms driving this detrimental remodeling process.

Area of Science:

  • Cardiology
  • Heart Failure Research
  • Cardiac Physiology

Background:

  • Natural history studies link increased left ventricular (LV) volume and mass to poor prognosis in heart failure.
  • Cardiac remodeling is crucial in heart failure progression, yet its underlying mechanisms remain poorly understood.

Purpose of the Study:

  • To review current clinical and experimental findings on cardiac remodeling in heart failure.
  • To provide an integrated perspective on the mechanisms of LV remodeling at cellular, myocardial, and chamber levels.

Main Methods:

  • Literature review of recent clinical and experimental studies.
  • Synthesis of data on the mechanisms contributing to left ventricular remodeling.

Main Results:

  • Increased LV volume and mass correlate with decreased LV performance and adverse clinical outcomes.
  • Remodeling mechanisms operate at multiple biological levels, from cellular changes to chamber dynamics.

Conclusions:

  • Understanding the mechanisms of cardiac remodeling is essential for improving heart failure management.
  • Further research into cellular and myocardial pathways is needed to target LV remodeling effectively.

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