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Updated: Aug 7, 2026
Metabolic Pathway Confirmation and Discovery Through 13C-labeling of Proteinogenic Amino Acids
Published on: January 26, 2012
Kinetic study of apo B100 containing lipoprotein metabolism using amino acids labeled with stable isotopes:
C Maugeais1, K Ouguerram, M Krempf
1Centre de Recherche en Nutrition Humaine, Hôtel Dieu, Nantes, France.
Abstract:
Kinetic disturbances of lipoprotein metabolism are important to know for a better understanding of lipid diseases or effects of drugs. These kinetic aspects were previously studied with radioactive tracers. The ethical concerns related to these tracers can be now overcome at a reasonable cost with the new development of small bench top mass spectrometers and the increased production of stable isotope tracers. In this review, we will discuss some methodological aspects related to stable isotope tracers and the analysis of the data with non-compartmental or compartmental models.
