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Related Concept Videos

Lethal Alleles02:41

Lethal Alleles

Agouti: A Lethal Allele
Lucien Cuénot discovered lethal alleles in 1905 while studying the inheritance of coat color in mice. The agouti gene is responsible for the color of the coat in mice. This gene codes for an agouti-signaling protein, which is responsible for melanin distribution in mammals. The wild-type allele gives rise to gray-brown coat color in mice, while the mutant allele gives rise to yellow coat color. In addition to coat color, the agouti gene is associated with the yellow...
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Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

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Generation of Genetically Modified Mice through the Microinjection of Oocytes
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Genetics of mouse growth

A Efstratiadis1

  • 1Department of Genetics and Development, Columbia University, New York, NY 10032, USA. arg@cuccfa.ccc.columbia.edu

The International Journal of Developmental Biology
|December 16, 1998
PubMed
Summary

Mammalian organism size is limited by cellular division rates, controlled by genes influencing growth pathways. Understanding these genetic mechanisms and their coordination with development remains a key research area.

Area of Science:

  • Developmental Biology
  • Genetics
  • Cell Biology

Background:

  • Organismal size is determined by cell division rates and duration.
  • Gene regulation orchestrates growth pathways, influencing cell division.
  • Growth factors and hormones play a role in growth signaling.

Purpose of the Study:

  • To explore the genetic regulation of mammalian growth.
  • To understand the role of cell cycle control in determining organism size.
  • To investigate the coordination of growth with developmental processes.

Main Methods:

  • Analysis of transgenic and gene knockout experiments.
  • Studying gene functions in growth-promoting and inhibiting pathways.
  • Investigating systemic and local effects of growth control genes.

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Last Updated: Jun 16, 2026

Generation of Genetically Modified Mice through the Microinjection of Oocytes
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Published on: June 15, 2017

Determination of Reproductive Competence by Confirming Pubertal Onset and Performing a Fertility Assay in Mice and Rats
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Determination of Reproductive Competence by Confirming Pubertal Onset and Performing a Fertility Assay in Mice and Rats

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Main Results:

  • Transgenic and knockout studies highlight key growth control genes.
  • Confirmed the involvement of growth factors and hormones in signaling pathways.
  • Revealed the complexity of gene-orchestrated growth regulation.

Conclusions:

  • Mammalian growth is primarily limited by cellular division dynamics.
  • Genetic pathways intricately control cell division rates and organismal size.
  • Further research is needed to elucidate mechanistic details of growth coordination with development.