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Related Experiment Videos

Cerebellar pressor response in the dog

K J Dormer, H L Stone

    Journal of Applied Physiology
    |October 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Stimulating the fastigial nucleus in dogs causes significant increases in blood pressure and heart rate. Baroreceptor reflexes modulate the heart rate response, but not the blood pressure increase.

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    Area of Science:

    • Cardiovascular Physiology
    • Neuroscience

    Background:

    • The fastigial nucleus plays a role in cardiovascular regulation.
    • Understanding its pressor and tachycardic responses is crucial for cardiovascular control research.

    Purpose of the Study:

    • To investigate the fastigial pressor response and associated tachycardia in anesthetized dogs.
    • To determine the influence of baroreceptor reflexes on these responses.

    Main Methods:

    • Electrical stimulation of the rostral fastigial nucleus in mongrel dogs.
    • Monitoring of mean arterial pressure and heart rate.
    • Carotid sinus isolation and bilateral vagotomy were performed to assess baroreceptor reflex involvement.

    Main Results:

    • Fastigial nucleus stimulation elicited substantial increases in mean arterial pressure (up to 150 mmHg) and heart rate (up to 190 beats/min).

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  • Tachycardia was transient and often followed by a decline in heart rate, while arterial pressure remained elevated.
  • Sustained tachycardia occurred after carotid sinus isolation or vagotomy, indicating baroreceptor reflex buffering of the cardiac response.
  • The pressor response and tachycardia showed a linear relationship with stimulus intensity up to 0.4 mA.
  • Responses were observed even under anesthesia with alpha-chloralose or barbiturates.

    • Conclusions:

    • The fastigial nucleus elicits a potent pressor response and a baroreceptor-modulated tachycardia.
    • Widespread sympathetic activation underlies both components of the response.
    • Baroreceptor reflexes primarily buffer the cardiac component, not the pressor component, of the fastigial nucleus response.