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Ochrobactrum intermedium infection after liver transplantation

L V Möller1, J P Arends, H J Harmsen

  • 1Department of Medical Microbiology, University Hospital Groningen and Laboratory for Public Health Groningen, University Hospital Groningen, Groningen, The Netherlands. streeklab@compuserve.com

Journal of Clinical Microbiology
|December 17, 1998
PubMed
Summary

A rare Ochrobactrum intermedium bacteremia with liver abscesses occurred in a liver transplant patient. This suggests gastrointestinal spread to the transplanted organ, highlighting a potential complication in immunocompromised individuals.

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Area of Science:

  • Microbiology
  • Transplant Surgery
  • Infectious Diseases

Background:

  • Orthotopic liver transplantation (OLT) recipients are immunocompromised, increasing susceptibility to opportunistic infections.
  • Bacteremia in transplant patients can lead to severe complications, including graft dysfunction and abscess formation.

Observation:

  • A case of bacteremia caused by Ochrobactrum intermedium was identified in an OLT recipient.
  • The patient also presented with concurrent liver abscesses.
  • Ochrobactrum intermedium was isolated from both fecal samples and liver abscess aspirates.

Findings:

  • The identical microbial isolates from stool and liver abscesses suggest a gastrointestinal origin and spread to the liver graft.
  • 16S DNA sequencing confirmed the pathogen as Ochrobactrum intermedium, a species closely related to Ochrobactrum anthropi and Brucella spp.

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Implications:

  • This case highlights the potential for gastrointestinal-originating pathogens like Ochrobactrum intermedium to cause invasive infections in OLT recipients.
  • Early identification and source control are crucial for managing such infections and improving patient outcomes.
  • Further research into the pathogenicity and transmission routes of Ochrobactrum intermedium in immunocompromised hosts is warranted.