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Hypoplastic anaemia complicating myxoedema coma
S H Song1, C J McCallum, I W Campbell
1Medical Unit, Victoria Hospital, Kirkcaldy, Fife.
Scottish Medical Journal
|December 17, 1998
Summary
Myxedema coma in a 68-year-old woman was linked to pancytopenia and hypoplastic anemia. Treatment with thyroid hormone replacement therapy resolved both the anemia and bone marrow abnormalities.
Area of Science:
- Endocrinology
- Hematology
Background:
- Myxedema coma, a severe manifestation of hypothyroidism, can present with diverse hematological abnormalities.
- Anemia is a common comorbidity in patients with hypothyroidism.
Observation:
- A 68-year-old female presented with myxedema coma and was found to be anemic (hemoglobin 8.2 g/dL).
- Further investigations revealed pancytopenia and hypoplastic anemia, confirmed by bone marrow biopsy.
Findings:
- The patient's condition improved with intravenous tri-iodothyronine (T3) followed by oral thyroxine (T4) replacement.
- Hematological parameters normalized, and bone marrow examination returned to normal post-treatment.
Implications:
- This case highlights the potential link between severe hypothyroidism and hypoplastic anemia with pancytopenia.
- Thyroid hormone replacement therapy can effectively reverse these hematological abnormalities, emphasizing the importance of comprehensive evaluation in myxedema coma.