Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Stress and the developing limbic-hypothalamic-pituitary-adrenal axis

D M Vázquez1

  • 1Mental Health Research Institute, University of Michigan, Ann Arbor 48109-0646, USA. dmVazq@umich.edu

Psychoneuroendocrinology
|December 17, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Avoiding being dragged away: finding egg cases of Schroederichthys bivius (Chondrichthyes: Scyliorhinidae) associated with benthic invertebrates.

Journal of fish biology·2017
Same author

Egg cases of the graytail skate Bathyraja griseocauda and the cuphead skate Bathyraja scaphiops from the south-west Atlantic Ocean.

Journal of fish biology·2017
Same author

Short-term adrenalectomy increases glucocorticoid and mineralocorticoid receptor mRNA in selective areas of the developing hippocampus.

Molecular and cellular neurosciences·2009
Same author

Hydrocortisone administration for the treatment of refractory hypotension in critically ill newborns.

Journal of perinatology : official journal of the California Perinatal Association·2008
Same author

Behavioral/environmental intervention improves learning after cerebral hypoxia-ischemia in rats.

Stroke·2001
Same author

Low cortisol and a flattening of expected daytime rhythm: potential indices of risk in human development.

Development and psychopathology·2001

The developing rodent

Area of Science:

  • Neuroendocrinology
  • Developmental Biology
  • Stress Physiology

Background:

  • The postnatal limbic-hypothalamic-pituitary-adrenal (LHPA) axis differs significantly from the adult form in rodents.
  • Early life is characterized by a stress hyporesponsive period (SHRP) followed by impaired glucocorticoid termination.

Purpose of the Study:

  • To review research on the regulatory biology of the LHPA system during development.
  • To examine the consequences of LHPA disruption on adaptive responses in young organisms.

Main Methods:

  • Comparative analysis of LHPA axis responses in developing versus adult rodents under stress.
  • Investigation of molecular and physiological changes in response to stress and maternal deprivation.

Main Results:

Related Experiment Videos

  • Developing rodents exhibit distinct responses to chronic stress (post-translational vs. genomic events).
  • Evidence of impaired feedback regulation and altered ACTH clearance in weanling rodents.
  • Maternal deprivation leads to sustained ACTH/corticosterone release and altered hippocampal receptor expression.

Conclusions:

  • LHPA axis development is dynamic, age-dependent, and employs different strategies than adult stress coping mechanisms.
  • Disruptions in early life LHPA function, potentially involving mineralocorticoid/glucocorticoid receptor balance, have lasting effects.