[Our experience in introducing current antibiotic prophylaxis into abdominal surgery--the initial results]

Area of Science:

• Surgical Infectious Diseases
• Pharmacology
• Microbiology

Context:

• Evaluates perioperative antibiotic prophylaxis in 154 emergency surgery patients over one year.
• Assesses antibiotic regimens against specific surgical interventions and patient risk factors.
• Considers local economic and hospital conditions in drug scheme development.

Purpose:

• To assess the clinical efficacy and safety of tailored perioperative antibiotic prophylaxis in emergency surgery.
• To establish evidence-based antibiotic drug schemes aligned with Bulgarian healthcare standards.
• To analyze complications associated with antibiotic prophylaxis and surgical procedures.

Summary:

• Developed and implemented specific intravenous antibiotic prophylaxis regimens for various emergency surgical procedures.
• Administered single-dose antibiotics pre-anesthesia, including cephalotin/cefazolin, metronidazole, amoxicillin/clavulanate, and cefotetan.
• Observed a low incidence of procedure-related complications (10 cases), with most postoperative periods being complication-free (135 patients).

Impact:

• Demonstrates the effectiveness of adapted antibiotic prophylaxis protocols in reducing surgical site infections and complications.
• Provides a model for optimizing antibiotic use in emergency surgery within resource-specific settings.
• Highlights the importance of aseptic techniques and intrahospital environment improvement for patient safety.