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Spectrum of disorders associated with enlarged sylvian fissures in infancy

P M Bingham1, B Parrish, S C Chen

  • 1Division of Neurology, Children's Hospital of Philadelphia, PA 19104, USA.

Neurology
|December 17, 1998
PubMed

Insights

Enlarged sylvian fissures in infants may indicate opercular cortex underdevelopment. This finding is often linked to feeding issues and facial differences, suggesting an early developmental connection.

Area of Science:

  • Neuroimaging
  • Developmental Biology
  • Pediatric Neurology

Background:

  • Disproportionate enlargement of the sylvian fissures (ESF) on infant Magnetic Resonance Imaging (MRI) is a radiological finding.
  • This finding suggests an underlying underdevelopment of the cortical operculum, a key brain region.

Purpose of the Study:

  • To investigate the clinical conditions associated with isolated ESF in infants.
  • To explore potential embryologic links between opercular cortex development and facial morphogenesis.

Main Methods:

  • Retrospective chart review of infants diagnosed with isolated ESF.
  • Analysis of associated clinical conditions, including feeding difficulties and facial dysmorphism.

Main Results:

  • Infants with isolated ESF frequently presented with feeding difficulties.
  • Facial dysmorphism, both syndromic and nonsyndromic, was also associated with ESF.
  • These findings suggest a potential shared developmental pathway.

Conclusions:

  • Isolated ESF in infants warrants further investigation for associated clinical conditions.
  • There is a potential embryologic relationship between the development of the opercular cortex and facial structures.
  • This highlights a possible link between central nervous system development and craniofacial anomalies.

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