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Resistance to activated protein C and the leiden mutation: high prevalence in patients with abruptio placentae
Z Wiener-Megnagi1, I Ben-Shlomo, Y Goldberg
1Department of Obstetrics and Gynecology, HaEmek Medical Center, and The Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Afula, Israel.
Objective:
The Leiden mutation, a point mutation in the gene encoding coagulation factor V, is associated with a high frequency of thromboembolic phenomena. It has recently been connected with adverse outcomes of pregnancy. We carried out this study to define its connection with abruptio placentae.
Study Design:
Twenty-seven women who had abruptio placentae and 29 control subjects matched for age, parity, and ethnic origin were studied. We studied all women for possible hypercoagulation defects. All women demonstrating resistance to activated protein C were studied for the presence of the factor V Leiden mutation.
Results:
Seventeen of 27 case patients had an activated protein C ratio
Conclusion:
Factor V Leiden mutation was found quite frequently in patients with abruptio placentae.
