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Antigenic and nucleotide characterization of a herpesvirus isolated from Pacific harbor seals (Phoca vitulina

D P King¹, R Parselles, F M Gulland

¹Marine Mammal Center, Sausalito, California, USA.

Archives of Virology

|December 18, 1998

Abstract:

This report describes the antigenic and nucleotide characterization of a herpes-like virus that has been isolated from the adrenal tissues of neonatal Pacific harbor seals. Infection with this virus has been previously implicated as a major cause of death of animals undergoing rehabilitation. Comparison and phylogenetic analysis of sequenced fragments of the DNA polymerase, glycoprotein B and glycoprotein D genes, and immunofluorescence assay using herpesvirus-specific monoclonal antibodies, demonstrated close similarity of the Pacific harbor seal herpesvirus to European isolates of phocid herpesvirus-1 (PHV-1) and other alpha-herpesviruses affecting terrestrial carnivores.

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