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Artificial endometrial preparation for oocyte donation using synthetic estrogen and progestogen
A Abu-Musa1, A Hannoun, A Khalil
1Department of Obstetrics and Gynecology, American University of Beirut-Medical Center, Lebanon.
Objective:
To evaluate the outcome of an oocyte donation program using synthetic estrogen and progestational agents for uterine preparation.
Methods:
Conjugated estrogen, 1.25 mg per day at increasing doses and dydrogesterone, a synthetic progestogen, 30 mg per day were used for uterine priming. All embryo transfers were done on day 2 of progestogen supplementation.
Results:
The pregnancy rates were 38% per embryo transfer. The ongoing pregnancy rate was 31% with an abortion rate of 20%.
Conclusion:
Endometrial preparation in an oocyte donation program using orally administered synthetic estrogen and progestogen gives pregnancy rates comparable to those reported with natural products.