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Is there a safe anticoagulation protocol for pregnant women with prosthetic valves?
M S Arnaout1, H Kazma, A Khalil
1Department of Internal Medicine, American University of Beirut, Medical Centre, Lebanon.
Clinical and Experimental Obstetrics & Gynecology
|December 18, 1998
Abstract:
We studied the outcome of 41 pregnancies in an attempt to identify an appropriate and safe anticoagulant regimen for pregnant women with cardiac valve prosthesis. The cumulative number of events: (neonatal death, premature deliveries, intrauterine fetal death and spontaneous abortion) was 66.6%, 20%, 12.5% and 20% in the Coumadin, Fraxiparine, Heparin and porcine valve groups, respectively. We conclude that in pregnant women with mechanical heart valves, low molecular weight heparin therapy is a superior strategy compared to warfarin.