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Related Experiment Videos

Circulating soluble CD5 in atopic dermatitis

G W Noh1, K Y Lee

  • 1Department of Pediatrics, Sungkyunkwan University College of Medicine, Samsung Cheil Hospital, Seoul, Korea. avdream@samsung.co.kr

Molecules and Cells
|December 18, 1998
PubMed
Summary
This summary is machine-generated.

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Soluble CD5 was detected in atopic dermatitis patients, but not in healthy individuals, suggesting its role in the condition. CD5 is primarily expressed on T-cells, indicating a potential T-cell origin for soluble CD5.

Area of Science:

  • Immunology
  • Dermatology

Background:

  • T-cell function is dysregulated in atopic dermatitis.
  • The role of CD5 in atopic dermatitis and the presence of soluble CD5 have not been previously investigated.

Purpose of the Study:

  • To investigate the presence of circulating soluble CD5 and CD5 mRNA expression in patients with atopic dermatitis.

Main Methods:

  • Peripheral blood mononuclear cells and plasma were analyzed from atopic dermatitis patients, febrile patients, and healthy controls.
  • T- and B-cells were isolated using immunomagnetic beads.
  • CD5 mRNA expression was assessed using reverse transcription polymerase chain reaction, and soluble CD5 was detected via immunoblotting.

Main Results:

  • Circulating soluble CD5 was detected in 4 out of 5 atopic dermatitis patients, but not in febrile patients or healthy controls.

Related Experiment Videos

  • CD5 mRNA expression was found in all atopic dermatitis and febrile patients.
  • CD5 mRNA expression was exclusively detected in T-cells from atopic dermatitis patients.

    • Conclusions:

    • Circulating soluble CD5 may play a role in the pathogenesis of atopic dermatitis.
    • Soluble CD5 is likely produced by T-cells in atopic dermatitis patients.