Related Experiment Video
Updated: Aug 5, 2026
06:25
Long-Term Catheterization of the Intestinal Lymph Trunk and Collection of Lymph in Neonatal Pigs
Published on: March 5, 2016
Lipoblastoma presenting as a mesenteric mass in an infant
Y Posey1, E Valdivia, D L Persons
1Department of Pediatrics, University of Kansas Medical Center, Kansas City 66160-7358, USA.
Journal of Pediatric Hematology/Oncology
|December 18, 1998
Summary
A rare infant lipoblastoma caused significant abdominal mass and hypertension. Cytogenetic analysis identified a specific translocation on chromosome 8, a potential marker for this benign tumor.
Area of Science:
- Pediatric Oncology
- Medical Genetics
Background:
- Lipoblastoma is a rare, benign tumor of infancy characterized by rapid growth.
- Abdominal lipoblastomas can present as large masses, potentially causing organ compression and secondary medical issues like hypertension.
Observation:
- A 5-month-old infant presented with diarrhea and a large right-sided abdominal mass.
- Imaging revealed a hypodense mass compressing the right kidney, causing hydronephrosis.
- Surgical exploration identified the mass adhered to the transverse colon and mesentery.
Findings:
- Histopathological examination confirmed the mass as an encapsulated lipoblastoma.
- Cytogenetic analysis revealed a 46,XX karyotype with a reciprocal translocation between chromosomes 2 and 8 (t(2;8)(q23;q11.2)).
Implications:
- Lipoblastoma, though benign, can lead to severe complications due to mass effect on adjacent organs.
- The translocation involving chromosome 8 band q11.2 may serve as a specific cytogenetic marker for lipoblastoma, aiding in diagnosis and understanding.
